Efficient Delivery of ADHD Medication

Daytrana Exhibited a Smoothly Increasing PK Profile Across Dosage Strengths

• Smoothly ascending and descending blood levels no matter when the patch is removed
• Ascending plasma concentration curves resulted from efficient delivery of methylphenidate directly through the skin and into the bloodstream, bypassing the stomach
• The effects of the patch are demonstrated at two hours and continue for three hours after removal of the patch at the maximum 9-hour wear time and for 2 hours after 4- or 6-hour wear time

Mean plasma concentration of d-MPH
in pediatric patients treated with Daytrana.

Lower limit of quantification (0.25 ng/mL).

Study 201: Drug concentration from multiple-dose administration of Daytrana^® in a randomized, double-blind, placebo controlled laboratory classroom study. Plasma samples were obtained for pharmacokinetic analysis at predose and 2, 3, 4.5, 6, 7.5, 9, 10.5, and 12 hours after dose administration.